Application in patients with Rheumatoid Arthritis and Osteoarthritis
Several studies have shown that oral intake of low doses of native chicken collagen have positive effects on symptoms
such as joint swelling and joint pain in patients with RA, strongly indicating a dampening of the chronic inflammation present in these patients (Barnett, Combitchi and Trentham, 1996; Barnett et al., 1998).
The mechanism of action is thought to be by oral tolerance. Oral tolerance is initiated, when an antigen, in this case native chicken collagen type Ⅱ, passes through the gut and the gut-associated-lymphoid-tissue induces systemic tolerance towards that antigen through the activation of regulatory T-cells (Weiner and Wu, 2011).
Additionally, a recent study indicates that the joint pain of OA can be relieved by oral intake of native chicken collagen type Ⅱ (Bakilan et al., 2016).
Rheumatoid Arthritis and Osteoarthritis
In patients with rheumatoid arthritis (RA) the joints and hyaline cartilage is attacked by the patient’s own immune system, making RA an autoimmune disease. In Osteoarthritis (OA) the joints and hyaline cartilage is broken down due to high levels of joint stress, which could be caused by overweight, previous injuries or jobs involving heavy labour.
Chemical structure of a triple helix formed by 3 collagen molecules.
(Hydrogens are omitted for clarity. Coloring per atom (upper image) and per stand (lower image)).
The most prevalent type of cartilage in human body is Hyaline cartilage and is present at the joints where it forms an elastic tissue protecting the bones and reducing friction when the body is in motion. The most abundant protein (80-90 %) in hyaline cartilage is type Ⅱ collagen making it an interesting target of research in the fields of RA and OA.
Native type Ⅱ collagen consists of a triple-helical structure of three interconnected (cross-linked) collagen fibers. The studies suggest that the native three-dimensional structure might play an important role in initiating a mechanism of oral tolerance resulting in positive effect for patients with RA and OA.
The article is sourced from BIOFAC.
Bakilan, F. et al. (2016) ‘Effects of Native Type Ⅱ Collagen Treatment on Knee Osteoarthritis: A Randomized Controlled Trial’, The Eurasian Journal of Medicine.
doi: 10.5152/ eurasianjmed.2015.15030.
Barnett, M. L. et al. (1998) ‘Treatment of rheumatoid arthritis with oral type Ⅱ collagen.
Results of a multicenter, double-blind, placebo-controlled trial.’, Arthritis and rheumatism.
Barnett, M. L., Combitchi, D. and Trentham, D. E. (1996) ‘A pilot trial of oral type Ⅱ collagen in the treatment of juvenile rheumatoid arthritis.’, Arthritis and rheumatism.
Weiner, H. L. and Wu, H. Y. (2011) ‘Oral tolerance.’,
Immunologic research. doi: 10.1385/IR:28:3:265.
Low daily dose for effective treatment
To initiate the oral tolerance mechanism and provide effective treatment opportunity for patients with joint pain a dose of maximum 40mg a day* is recommended..