Native Chicken Collagen type Ⅱ for Joint Health

Several studies have shown that oral intake of low doses of native chicken collagen type Ⅱ has positive effects in patients with Rheumatoid Arthritis and Osteoarthritis.

Application in patients with Rheumatoid Arthritis and Osteoarthritis

Several studies have shown that oral intake of low doses of native chicken collagen have positive effects on symptoms
such as joint swelling and joint pain in patients with RA, strongly indicating a dampening of the chronic inflammation present in these patients (Barnett, Combitchi and Trentham, 1996; Barnett et al., 1998).

The mechanism of action is thought to be by oral tolerance. Oral tolerance is initiated, when an antigen, in this case native chicken collagen type Ⅱ, passes through the gut and the gut-associated-lymphoid-tissue induces systemic tolerance towards that antigen through the activation of regulatory T-cells (Weiner and Wu, 2011).

Additionally, a recent study indicates that the joint pain of OA can be relieved by oral intake of native chicken collagen type Ⅱ (Bakilan et al., 2016).

Rheumatoid Arthritis and Osteoarthritis

In patients with rheumatoid arthritis (RA) the joints and hyaline cartilage is attacked by the patient’s own immune system, making RA an autoimmune disease. In Osteoarthritis (OA) the joints and hyaline cartilage is broken down due to high levels of joint stress, which could be caused by overweight, previous injuries or jobs involving heavy labour.


Chemical structure of a triple helix formed by 3 collagen molecules.

(Hydrogens are omitted for clarity. Coloring per atom (upper image) and per stand (lower image)).
The most prevalent type of cartilage in human body is Hyaline cartilage and is present at the joints where it forms an elastic tissue protecting the bones and reducing friction when the body is in motion. The most abundant protein (80-90 %) in hyaline cartilage is type Ⅱ collagen making it an interesting target of research in the fields of RA and OA.

Native type Ⅱ collagen consists of a triple-helical structure of three interconnected (cross-linked) collagen fibers. The studies suggest that the native three-dimensional structure might play an important role in initiating a mechanism of oral tolerance resulting in positive effect for patients with RA and OA.

The article is sourced from BIOFAC.

Scientific references:
Bakilan, F. et al. (2016) ‘Effects of Native Type Ⅱ Collagen Treatment on Knee Osteoarthritis: A Randomized Controlled Trial’, The Eurasian Journal of Medicine.
doi: 10.5152/ eurasianjmed.2015.15030.
Barnett, M. L. et al. (1998) ‘Treatment of rheumatoid arthritis with oral type Ⅱ collagen.
Results of a multicenter, double-blind, placebo-controlled trial.’, Arthritis and rheumatism.
doi: 10.1002/1529-0131(199802)41:2<290::AID-ART13>3.0.CO;2-R.
Barnett, M. L., Combitchi, D. and Trentham, D. E. (1996) ‘A pilot trial of oral type Ⅱ collagen in the treatment of juvenile rheumatoid arthritis.’, Arthritis and rheumatism.
Weiner, H. L. and Wu, H. Y. (2011) ‘Oral tolerance.’,
Immunologic research. doi: 10.1385/IR:28:3:265.

Low daily dose for effective treatment

To initiate the oral tolerance mechanism and provide effective treatment opportunity for patients with joint pain a dose of maximum 40mg a day* is recommended..

Scan Your Medication with eMeds, Sweep Away All Your Worries

Reminding and Recording Medication:

First, enter the eMeds system or eMeds App through website.
Write the drug information and usage into the lid of smart cap through cell phone or computer and then fill the bottle with drug.
If the drug name on cell phone is consistent with the medication information on the bottle, click the clock icon to automatically set the medication reminding according to the preset personal schedule.

Associated Person Reminds of Medication :

The associate person could be relatives, social worker, nurse and nursing workers in nursing home.
Set the relative person in the eMeds system and then connect it to the cell phone, or use the eMeds APP to produce the patient’s QR Code.
Scan the OR code to establish connection.
Social worker, nurse and nursing workers in nursing home could establish connection with more than one patients to care about the patients’ medication.

Monitor Ensures Medication to be Taken:

It is mandatory that patients of infectious disease (for epidemic prevention purpose), drug addicts and dementia patients be supervised for medication. The supervisor could be police officer in the neighborhood, nurse, social worker, relatives or precint head. Scanning the QR code of the patients with their own cell phones, they can start to supervise the medication of patients. When all drugs are taken by the patients, they click “I have completed medication supervision” which will be recorded in the eMeds system and cell phone of the patient.

Medication Record can be Inquired :

General patients of chronic disease will go through various examinations when they return to hospital for check-ups. The doctor will assess whether the patient’s condition has improved after a period of prescriped medication and adjust the prescription based on the medication record collected from eMeds system. Through eMeds system, the doctor can learn about every patient’s medication record so as to arrange examination and adjust prescription.

The operation procedure is easy. Apply to gain access to the medicaton record of the patient. Enter the eMeds system through patient’s cell phone or the website of eMeds. Put in the temporary password sent to the patient to check the patient’s medication record.

Alert PIM to Repeated Prescription:

Every patient might see doctor of more than two departments in one day. When the patient is prescripted the same medicine, the eMeds sysem will alert the pharmacist to the medicine name or the eMeds APP will alert to the same medicine name to prevent the patients from taking the same medicine.